Photodynamic therapy - Lasers and Energy Devices for the Skin - page 245

Table 10.5 Published Clinical Studies on ALA- and MAL-PDT for Photorejuvenation

Location of
Photodamage/
Study Design

Incubation
Period (hr)

Light Source
(Emission λ , nm)

Reference ALA Preparation # Patients Response Follow-up (mo)

Ruiz-Rodriguez (166)
(2002)

20% Emulsion Face and scalp,

≥ 1 AK and
chronic
photodamage;
2 PDT sessions

4, Occluded 17 (38 AKs) IPL (590-1200) 87% CR of AKs;

excellent cosmesis

3

Goldman (72) (2003) 20% Solution Face, long-

incubation PDT

15-20 32 Blue light (417) 94% CR of AKs;

improved skin
texture, pigmenta-
tion

3-6

1

Smith (81) (2003) 20% Solution,

2 sessions

Face, scalp 1 35 Blue light (417) or

PDL (595)

80% CR for AKs
with blue light;
60% CR for PDL;
both demon-
strated improve-
ment in global
photodamage,
tactile roughness,
and hyperpigmen-
tation

Touma (22) (2004) 20% Solution Facial AK and

mild-to-moderate
photodamage

1-3 17 Blue light (417) Improvement in

photodamage
markers, including
skin quality, fi ne
rhytides, and
sallowness

1-5

Avram (178) (2004) 20% Solution Facial photodamage

(with AKs) treated
with 1 ALA-IPL
session

1 17 IPL 69% CR of AKs;

improvement in
telangiectasias,
dyspigmentation,
skin texture

3

( Continued )