Biomedical Engineering Reference
In-Depth Information
Table 10.4
Published Clinical Studies on ALA- and MAL-PDT for Nodular Basal Cell Carcinoma (
Continued
)
Light Source
(Wavelength
in nm)
MAL-PDT Study
Design
Incubation
Period (hr)
# Lesions Treated
(# Patients)
Reference
Location
Response Rate
Follow-up (mo)
Kuijpers (156) (2006)
2×MAL-PDT ×
2× ALA-PDT
(20% cream)
7 days apart
(lesion
preparation)
Face, neck, trunk,
and extremities
3, Occluded
43 (22 Treated with
ALA-PDT and
21 with
MAL-PDT)
Broadband
halogen light
(600-730 nm),
dose of
75 J/cm
2
, light
intensity of
100 mW/cm
2
CR at 2 mo
(histologically
controlled):
72.7% with
ALA-PDT vs.
71.4% with
MAL-PDT
8
Rhodes (160) (2007)
2×MAL-PDT
7 days apart
(repeated if
necessary, lesion
preparation) ×
surgery
Face, scalp, neck,
trunk, and
extremities
3, Occluded
105 (53 treated with
MAL-PDT)
Red light
(570-670 nm),
dose of 75 J/cm
2
,
light intensity of
50-200 mW/cm
2
Sustained CR at
5 years:
MAL-PDT 76% vs.
surgery 96% ;
recurrence at 5 yr:
14% in the
MAL-PDT vs. 4%
in the surgery
group
60
Surrenti (268) (2007)
2× MAL-PDT
(7 days apart)
with additional
monthly MAL-
PDT sessions up
to a maximum
8 where necessary
(lesion
preparation)
Face, neck, trunk,
and extremities
3, Occluded
24
Red LED light
source (634 ± 3
nm, 37 J/cm
2
, 50
mW/cm
2
)
52.2% CR 1 mo
after 2 sessions, no
additional clinical
benefi t beyond
2 MAL-PDT
sessions
12
Foley (161) (2009)
2× MAL-PDT
(7 days apart)
retreated after
3 mo if required
(lesion prepara-
tion) × placebo-
PDT for nBCC
<5 mm in depth
Face, scalp, neck,
trunk, and
extremities
3, Occluded
150 (75 lesions
treated with
MAL-PDT)
Red light
(570-670 nm),
dose of 75 J/cm
2
,
light intensity of
50-200 mW/cm
2
Histologically
verifi ed CR: 73%
with MAL-PDT
vs. 27% with the
Placebo-PDT
6
Fantini (269) (2010)
1 or 2× MAL-PDT
(7 days apart), a
third PDT session
after 3 mo if
required (lesion
preparation)
Head, neck, trunk,
and limbs
3, Occluded
78
Red LED light
source (634 ±
3 nm, 37 J/cm
2
,
50 mW/cm
2
)
CR:33%(tumor
thickness superior
o 0.5 mm and the
presence of
ulceration were
predictors of
negative outcome)
Mean of 23.5
Abbreviations
: ALA, aminolevulinic acid; CR, clearance rate; DMSO, dimethyl sulfoxide; EOD, every other day; LED, light-emitting diode; MAL, methyl aminolevulinic acid; nBCC, nodular basal cell carcinoma;
NR, nonresponse; sBCC, superfi cial basal cell carcinoma; PDT, photodynamic therapy.
