The Art of Bioconjugation: Functionalization of VNPs - Viral Nanoparticles: Tools for Materials Science and Biomedicine - page 111

b

Q Lys (E) Chelated

gadolinium
complexes

NHS-azide
followed by click
reactions

Contrast agents
for MRI

Prasuhn et

al . (2007,

2008)

Q b Lys (E) Carbohydrates NHS-alkyne

followed by click
reaction

Biomedical
targeting
approaches

Kaltgrad et

al . (2008)

Q b Lys (E) Polycationic

motifs (poly
Arg peptides)

NHS-azide and
-alkyne followed
by click reaction

Heparin
antagonist for
biomedical
applications

Udit et al .

(2009)

b

Q Lys (E) Nicotine NHS ester Nicotine vaccine

for smoking
cessation

Maurer et al .

(2005)

Ad

1

Lys (E) PEG NHS ester Development of

improved Ads
for gene delivery
with reduced
immunogenicity
and clearance

For reviews
see:
Singh and
Kostarelos
(2009),
Barnett

et

al . (2002),

Campos
and Barry
(2007),
Mizuguchi
and
Hayakawa
(2004)

A Lys (E) PEG-RGD NHS ester Retargeting

Ads for tissue-
specific gene
delivery

Eto .

(2005, 2008)

et al

Ad Lys (E) PEG-folic acid

and fluorescent
dyes

EDC/NHS Retargeting

Ads for tissue-
specific gene
delivery

Oh et al .

(2006)

Ad Lys (E) PEG-FGF Heterobivalent

linker (maleimide
and NHS ester)

Retargeting
Ads for tissue-
specific gene
delivery

Menezes et

al . (2006)

Ad Lys (E) Carbohydrates 2-Imino-2-

methoxyethyl-1-
thioglycosides

Retargeting
Ads for tissue-
specific gene
delivery

Pearce et al .

(2005)

Ad Cys (E; GE) Nanogold, PEG,

transferrin

Maleimide,
NHS ester, and
heterobivalent
linker

Retargeting
of Ad and
delivery of gold
nanoparticles
for biomedical
applications

Kreppel et al .

(2005)