Biomedical Engineering Reference
In-Depth Information
Table 1 (continued)
Positive/negative regulators
Soluble ligands/receptors
Impact on endothelial cells
Notes
Anti-angiogenic factors
Angiostatin
Inhibit EC proliferation
38 kDa plasminogen fragment [
118
]
Endostatin
Inhibit EC proliferation
20 kDa C-terminal collagen XVIII
fragment [
119
]
Interleukins (IL-4, IL-13)
Inhibit EC migration Inhibit tube
formation
Cytokine [
120
], [
121
]
Platelet factor-4 (PF4)
CXCR3-B
Inhibit EC proliferation
Inhibit EC migration
ELR-negative chemokine [
122
]
Thrombospondin-1(TSP-1)
Inhibit EC migration
[
123
]
Vasostatin
Inhibit EC proliferation
Fragment of calreticulin [
124
]
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