Biomedical Engineering Reference
In-Depth Information
PEGASYS (interferon-
a
-
2a)
Lysines 31, 121, 131, or 134,
amine PEGylation
40
2002 (USA,
EU)
O
O
O
NH
n
O
O
O
N
O
O
H
n
O
O
Neulasta (G-CSF)
N-Terminal methionine, amine
PEGylation
20
2002 (USA),
2003 (EU)
O
O
O
n
Somavert (hG11 antagonist
B2036)
Nonspecific, amine PEGylation
5
2002 (EU),
2003 (USA)
O
O
O
O
N
O
n
O
O
5
0
-Terminus of modified oligo
RNA, amine PEGylation
Macugen (anti-VEGF,
aptamer)
40
2004 (USA),
2006 (EU)
O
O
O
NH
n
O
O
O
N
O
O
N
H
n
O
O
Mircera (continuous
erythropoietin receptor
activator)
Lysines 52 or 46, amine
PEGylation
30
2007 (USA,
EU)
O
N
O
O
O
n
O
O
(continued)
