Biomedical Engineering Reference
In-Depth Information
Table 1 List of approved PEGylated drugs and their properties
PEG drug in formation
PEG
PEGylation
PEG size
(kDa)
Year of
approval
Adagen (adenosine
deaminase)
Nonspecific, amine PEGylation
5
1990 (USA)
O
O
O
N
O
n
O
O
Oncaspar (
L
-asparaginase)
Nonspecific, amine PEGylation
5
1994 (USA,
EU)
O
O
O
N
O
O
n
O
O
Doxil (PEGylated
liposome)
PEG possessing lipid moiety is
used as a component of
liposome
2
1995, 1999
(USA), 1996
(EU)
O
(CH
2
)
16
CH
3
H
2
C
O
C
Na
+
O
-
HC
O
C
(CH
2
)
16
CH
3
CH
2
CH
2
O
CH
3
O
O
C
NH
CH
2
CH
2
P
O
CH
2
O
n
O
O
PEG-INTRON (interferon-
a
-2b)
Histidine 34 (major), amine
PEGylation
12
2000 (EU),
2001 (USA)
O
O
O
O
O
N
n
O
