Biomedical Engineering Reference
In-Depth Information
Table 1 (continued)
PEG drug in formation
PEG
PEGylation
PEG size
(kDa)
Year of
approval
Cimzia (anti-TNF
a
, Fab
0
)
C-Terminal cysteine, thiol
PEGylation
40
2008, 2009
(USA), 2009
(EU)
O
O
NH
O
O
O
N
O
O
O
H
N
H
O
O
Krystexxa (mammalian
urate oxidase)
Nonspecific, amine PEGylation
10
2010 (USA)
NO
2
O
O
O
O
n
