Surface-Enhanced Raman Scattering-Based Bioimaging - Nanotechnology for Biomedical Imaging and Diagnostics - page 334

11.6 Summary and future perSpective

The future for Raman-based bioimaging certainly looks bright. although phenom-
enal progress has been made in the design and synthesis of ultrabright SERS probes,
there appears to be a slight disconnect between ultrabright probe development and
their testing in live subjects. Most of in vivo applications so far relied on simple
spherical nanoparticles, which are significantly dimmer compared to some of the
novel probes involving advanced plasmonic engineering and rational choice of
Raman reporters for a given excitation. This disconnection needs to be bridged in the
future to enable rigorous testing of Raman-based bioimaging in preclinical and
clinical settings. We also expect to see increased efforts in achieving multimodality
and multifunctionality, which aim at synergistically integrating complementary
bioimaging techniques or engineering nanostructures that can not only serve as
contrast agents but also serve as therapeutic agents (e.g., drug and gene delivery,
photothermal or photodynamic therapy). We believe that better understanding of
bio-/nanointerface, innovative instrumentation, and engineered probes will propel
Raman-based bioimaging into routine clinical applications.

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