Hollow Nanocapsules in Biomedical Imaging Applications - Nanotechnology for Biomedical Imaging and Diagnostics - page 95

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(b)

Nanocontainer
with ligand

Nanocontainer
without ligand

Cell localization Nanocontainer

localization

Merge

Figure 4.16 (a) TEm shows functionalized nanocontainers in THP-1 cells. (b)
Fluorescently labeled nanocontainer found at the surface and inside macrophages. (Reprinted
with permission from Ref. [73]. © Elsevier.)

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Figure 4.17 In vivo fluorescence image of 300 nm-sized NIR-emissive polymersomes
taken 10 min after direct tumor injection of a glioma-bearing rat. The fluorescence signal
intensity corresponded to only half the integrated emission from the polymersomes, and it
remained constant between successive images taken during a 20 min interval postinjection.
(Reprinted from Ref. [74]. © National Academy of Sciences.)