Environmental Engineering Reference
In-Depth Information
Table 9.2 (continued)
Route of
entry
Status/clinical trial
phase
Trade name with major usage
Chemical name
Formulations
Company
ECOVAX 0157 (
Escherichia
coli
vaccine)
Escherichia
coli
vaccine
Synthetic liposomes
Oral
Novavax, Rockville, MD,
USA
Phase I
Shigella flexneri 2a oral vaccine
(Shigella flexneri vaccine)
Shigella
flexneri
vaccine
Synthetic liposomes
Oral
Novavax, Rockville, MD,
USA
Phase I
Depocyt/Liposomal Ara-C
(Neoplastic meningitis and
lymphomatous meningitis)
Cytarabine
Liposomes (DOPC/DSPC/
DSPG/Chol/and triolein)
Suspension
(intrathecal)/
Spinal
Pacira (formerly
SkyePharma); DepoCyt
®
(Almac Pharma Services Ltd,
Craigavon, UK)
FDA regulated
usage from 2007
Abelcet (Severe fungal
infections)
Amphotericin
B (Amp B)
Liposomes (Lipid complex)
Suspension
(i.v.)
Enzon; Sigma-Tau Pharma-
ceuticals, Inc., Gaithersburg,
MD, USA
More than 10 years
in market
Amphotec (Severe fungal
infections)
Amphotericin
B (AmpB)
Liposomes (Lipid complex)
Suspension
(i.v.)
Ben Venue Laboratories,
Inc., Bedford, OH 44146,
USA
Effective from
1996
Myocet (Combination therapy
in breast cancer)
Doxorubicin
Liposome (powder) (Block
copolymeric micelles) EPC,
DPPC, MSPC, and DSPE-
PEG
2000
Suspension
(i.v.)
Zeneus; Enzon Pharmaceuti-
cals, Piscataway, NJ, USA)
Not yet approved
by the FDA for use
in the United States
Visudyne (Age related molecu-
lar degeneration/photodermal
therapy)
Verteporfin
Liposome, EPG and DMPC
Suspension
(i.v.)
Novartis
Rx for US only
DepoDur (Pain management,
post surgical analgesia)
Morphine
sulfate
Liposome; DOPC, DPPG, chol
and triolein
Epidural
Skype Pharma; Pacira Phar-
maceuticals, Inc
FDA approved in
2004
LEP-ETU/Taxol, ENDO-TAG1
(Ovarian, breast and lung can-
cers, Intravenous
Paclitaxel
Synthetic liposomes; DOTAP
and DOPC
Intravenous
NeoPharm, Inc. Paclitaxel
Phase I and II
