Environmental Engineering Reference
In-Depth Information
Route of
entry
Status/clinical trial
phase
Trade name with major usage
Chemical name
Formulations
Company
CPX-1 (Colorectal cancer)
Irinotecan
HCL and
floxuridine
Liposomes; DSPC, DSPG and
cholesterol
Intravenous
Phase II
Ventus (Acute respiratory dis-
tress syndrome)
Prostaglandin
E1 (PGE1)
Liposomal PGE1
Mechanical
ventilation
Liposome Co., Princeton, NJ,
USA
Phase III not
successful
Liposomal Nyotran (Fungal
infection)
Nystatin
Liposomes
Intravenous
Aronex, The Woodlands, TX,
USA
Phase III
Marqibo (Adult patients with
acute lymphoblastic leukemia)
Vincristine
sulfate
Liposomes; Egg
sphingomyelin and chol
Liposomal
injections
(i.v.)
Spectrum Pharmaceuticals;
Inex, Vancouver, BC,
Canada
Phase I
Liposomal Annamycin
(Antibreast cancer activity)
Annamycin
Liposomes; DSPC, DSPG and
tween
Intravenous
Aronex, The Woodlands, TX,
USA
Phase I/II
Epaxal (Hepatitis A)
Hepatitis-A
vaccine
Liposomes; LECIVA-S70
Intravenous
Cruceal; Swiss Serum Insti-
tute, Bern, Switzerland
On Swiss market
since 1994
Liposomal Trivalent influenza
vaccine/Inflexal Berna V
(Influenza)
Trivalent influ-
enza vaccine
Liposomes
Intravenous
Swiss Serum Institute, Bern,
Switzerland
Phase III
Atragen (Antirenal cell
carcinoma)
Retinoic acid
Liposomes, DMPC, and soy-
bean oil
Intravenous
Aronex, The Woodlands, TX,
USA
Phase I/II
Hepuman-Berna (Hepatitis B
vaccine)
Hepatitis B
vaccine
Liposomes
Intravenous
Swiss Serum Institute, Bern,
Switzerland
Phase I
Diphtheria, tetanus, influenza,
and hepatitis-A liposomes
Diphtheria, tet-
anus, influenza,
and hepatitis-A
Liposomes
Intravenous
Swiss Serum Institute, Bern,
Switzerland
Phase I
ELA-Max (Pain management in
children)
Lidocaine
Liposomal lidocaine
Topical anes-
thetics for
venipuncture
Biozone Labs, Pittsburgh,
CA, USA
In the US market
since 1998
