Environmental Engineering Reference
In-Depth Information
Route of
entry
Status/clinical trial
phase
Trade name with major usage
Chemical name
Formulations
Company
LEM-ETU (Leukemia, breast,
stomach, liver and ovarian
cancers)
Mitoxantrone
Liposome; DOPC, cholesterol,
and cardiolipin
Intravenous
Phase I
INX-0076 (Advanced solid
tumors)
Topotecan
Liposome; Egg
sphingomyelin, and chol
Intravenous
Phase I
INX-0125 (Breast, colon and
lung cancers)
Vinorelbine
Liposome; Egg sphingomyelin
and chol
Intravenous
Phase I
OSI-211 (Ovarian, head and
neck cancers)
Lurtotecan
Liposome; HSPC and
cholesterol
Intravenous
Phase II
Inflexal V (Infuenza)
Liposomal
IRIV vaccine
Liposome, LECIVA-S90
Intravenous
BERNA Biotech
There are several lipid-based commercially available drug formulations whose structure is micelar, mixed micellar, a liquid-crystalline suspension or a lipid-
stabilized emulsion. Several liposome-DNA complexes are also in various phases of clinical trials for different diseases.
IV
, intravenous;
DSPC
, 1,2-
distearoyl-sn-glycero-3-phosphocholine;
DSPE
, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine;
DSPG
, 1,2-distearoyl-sn-glycero-3-phosphoglycerol;
IP
,
intraperitoneal;
PC
, phosphatidylcholine;
PEG
, polyethylene glycol;
CHOL
, Cholesterol [
1
-
9
].
