Environmental Engineering Reference
In-Depth Information
Table 9.1 (continued)
Disease/cell
targeted/agent
Immunological
response
Liposome type
Formulation
Agent transported
Mechanism
References
NBD-PE or additionally loaded with
dexamethasone
PEG-(2000)-DSPE, NBD-PE and cholesterol was
prepared at a molar ratio of 1.85:0.15:0:1. A fluo-
rescent marker 1 mol % of (
N
-(7-Nitrobenz-2-oxa-
1,3-diazol-4-yl)-1,2-dihexadecanoyl-snglycero-3-
phosphoethanolamine, triethyl-ammonium salt)
NBD-PE was added to the organic phase in relation
to the total amount of lipid, including cholesterol.
The lipid film was hydrated at 50
C in an aqueous
solution of dexamethasone phosphate in a concen-
tration of 100 mg/mL at a phospholipid concentra-
tion of 100 mM
atherosclerosis, coli-
tis, and cancer,
to drug alone.
Altered Macro-
phage maturation
and polarization
markers. Induced
proinflammatory
cytokine secretion
(TNF, IL1
β
, IL6)
in unstimulated
cells, but reduced
in inflammatory
conditions.
Inhibited mono-
cyte and macro-
phage migration
SSM-Indisulam were prepared by
coprecipitation method
Indisulam solubi-
lized in sterically
stabilized micelles
(SSMs)
Mixed micelles containing indisulam were prepared
by mixing poly-(ethylene glycol-2000)-grafted
distearoyl phosphatidylethanolamine (DSPE-
PEG2000) and egg-phosphatidylcholine at optimal
molar ratio (90:10) and coprecipitation along with
indisulam
MCF-7 breast cancer
cell line
SSM is a promis-
ing nanocarrier for
indisulam
[
125
]
