Environmental Engineering Reference
In-Depth Information
Disease/cell
targeted/agent
Immunological
response
Liposome type
Formulation
Agent transported
Mechanism
References
O-palmitoyl amylopectin (OPA), a modi-
fied polysaccharide, anchored to drug,
dipyridamole (DIP) liposomes
Hydrophobic model
drug, dipyridamole
(DIP), used as a
coronary vasodilator
and antiplatelet
agent in medicine
EPC, cholesterol, and DIP (mass
ratio
ΒΌ
100:12:2.25) were dissolved in chloroform.
A thin film of dry lipid was hydrated at 40
C with
pH 7.4 PBS. Then, the OPA (formed by esterification
of amylopectin in DMSO) anchored DIP liposomes
(ODL) were prepared by anchoring O-palmitoyl
amylopectin on the surface of PDL
OPA anchored lipo-
somes increases DIP
stabilities against irra-
diation, disperse
medium, biofluid, and
long-term storage as
compared with only
liposomes
Male S-D rats
[
122
]
Phospholipid
-based nano-
particle
formulation
DOX-Loaded GAGs. Lipids
Glycosaminoglycan
hyaluronan, the
major ligand of
CD44, which is
upregulated and
undergoes different
splice variations in
many types of can-
cer cells
Lipids 1,2-dilauroyl-sn-glycero-3-phosphoetha-
nolamine (DLPE) and 1,2-dilauroyl-sn-glycero-3-
phosphoglycerol (DLPG) at a mole ratio of 9:1,
respectively, were dissolved in ethanol. After drying
and hydrating by MES buffer (0.1 M, pH 5.5) with or
without DOX (drug loading was 1:12 drug/lipid
(mol/mol). Activated HA (lipid/HA 10:1 (w/w) was
linked DSPE-PEG 2000 added to phosphate buffer
(pH 6.5, 7.4 or 8.0)/normal saline (pH 4.5-7.0), to
form micelles. PP in phosphate buffers or normal
saline was added to the SSM dispersion and allowed
to equilibrate for 2 h in the dark at 25
C
Monolayers of NCI/
ADR-RES (NAR)
(P-gp-overexpressing
human ovarian
adenocarcinomaDOX-
resistant), OVCAR-8 -
(DOX-sensitive cell
line), RAW264.7
(mouse macrophages)
cells.
DOX-GAG for-
mulation could
bypass the P-gp-
mediated drug
resistance pumps.
[
50
,
123
]
Pancreatic polypeptide (PP) in sterically
stabilized micelles (SSM)
Pancreatic polypep-
tide (PP)
SK-N-MC (human
neuroblastoma) cells
which endogenously
express PP specific Y4
receptors, treatment of
diabetes, obesity
PP-SSM confers
stability to the PP
against proteolytic
digestion
[
124
]
Liposomes (100 or 400 nm) were
PEGylated and subsets of liposomes were
either coated with the fluorescent dye
Dexamethasone
Prepared by the film method. A mixture of chloro-
form/methanol (10:1 volumetric ratio) containing
Dipalmitoyl phosphatidylcholine (DPPC),
Human primary blood
leukocytes, Rheuma-
toid arthritis,
Reduced cytotox-
icity in human
fibroblasts, macro-
[
125
]
