Environmental Engineering Reference
In-Depth Information
Table 9.1 (continued)
Disease/cell
targeted/agent
Immunological
response
Liposome type
Formulation
Agent transported
Mechanism
References
(5) OML coated
with Human Papil-
loma virus type
16 E6 and E7 with
OML coated papil-
loma virus
(6) HLA-A80201
restricted HTLV-1
(7) Tax peptide
Polysaccharide
anchored
liposomes
Cholesterol succinyl chitosan
anchored liposomes
Epirubicin
Amphiphilic cholesterol succinyl chitosan (CHCS)
conjugates were used as the anchoring materials to
coating on the liposome surface by the incubation
method. Compared with plain liposomes and
chitosan-coated liposomes (CCLs), Epirubicin as a
model drug, was effectively loaded into CALs. Drug
release sustained both in phosphate buffer solution
(PBS, pH 7.4) and 1 % (V/V) aqueous fetal bovine
serum (FBS)
Drug release tested on
Phosphate buffer and
FBS
ND
[
120
]
SPC-Cholesterol-R6H4-C18-HA
Paclitaxel (PTX)
SPC and Chol (20:1, w:w) were dissolved in chloro-
form. PTX with 3.3 % (w:w), C6 with 0.033 % (w:w)
and NIRD15 with 3.3 % (w:w) of the total lipids
weight were added to prepare drug-loaded
nanoliposomes, Cell-penetrating peptides(CPP)-mod-
ified liposomes (R6H4-L, R8-L) were obtained by
using stearyl CPP (R6H4-C18, R8-C18) as the hydra-
tion medium with 2.5 mol% of total lipids weight.
HA-coated CPP-modified liposomes (HA-R6H4-L,
Tumor-targeted drug
delivery. HA allowed
protection and accu-
mulates at the tumor
site. pH sensitivity
enhances the cellular
uptake of the lipo-
somes, cell penetrat-
ing effect of R6H4
HepG2 and A549
cells, Heps tumor
xenograft models
[
121
]
