Environmental Engineering Reference
In-Depth Information
Disease/cell
targeted/agent
Immunological
response
Liposome type
Formulation
Agent transported
Mechanism
References
Carboplatin-phospholipid formulation
Carboplatin, a
cisplatin-derived
anticancer drug
Carboplatin (5 mmol/L) in Milli-Q water solution
was added to a dry film of phospholipids
Carboplatin
nanocapsules formu-
lation reduced toxicity
of carboplastin alone
by 1,000-fold on car-
cinoma cell lines,
improved cytotoxicity
in IGROV-1 cells,
increased platinum
accumulation in the
cells, uptake of the
formulation by endo-
cytosis fasting dia-
betic rats
Ovarian Carci-
noma cell lines;
IGROV-1,
OVCAR-3,
A2780, NSC lung
carcinoma:NCI-
H522 and Renal
cell carcinoma:
A498 cell lines
[
126
]
Freeze-drying of emulsions for efficient
entrapment of drugs and controlled,
effective drug release phospholipid
Aqueous phase
containing insulin
and oil phase
containing
phosphatidylcholine
The water in oil type emulsions was prepared by
emulsification
A significant
reduction in the
plasma glucose
level of fasting
diabetic rats
after oral
administration
[
135
]
A mixture of cyclohexane/dichloromethane/diethyl
ether (4:1:1, v/v/v) was used as the organic solvent
for the emulsion outer oil phase (O). SPC Soybean
phosphatidylcholine dissolved in O to give lipid
solutions. Insulin was dissolved in water (0.5 mg/
mL) forming inner aqueous phase (W)
*
EE
, entrapment efficiency;
DL
, drug loading;
NR
, not reported;
HPESO
, hydrolyzed polymer of epoxidized soybean oil;
MDR
, multi-drug resistant;
PLGA
, poly(lactic-co-
glycolic acid);
DLPC
, dilinoleoylphosphatidylcholine;
DMPE-DTPA
, 1,2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid;
DSPE-PEG
, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)];
PMOXA-PDMSPMOXA
, poly(2-methyloxazoline)-block-poly
(dimethylsiloxan)-block-poly(2-methyloxazoline);
DPPC
, dipalmitoylphosphatidylcholine;
PEI
, polyethyleneimine;
EPC
, 1,2-dimyristoleoyl-sn-glycero-3-ethylpho-
sphocholine; PGA, poly(glutamic acid);
DPTAP
, 1,2-dipalmitoyl-3-trimethylammonium-propane; PLA,poly(lactic acid);
OQLCS
, octadecyl-quaternized lysine-modified
chitosan;
DHA
, cis-4,7,10,13,16,19-docosahexanoic acid;
PBAE
, poly-(
-amino ester);
MTT
, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;
MTS
, 3-(4,5-
dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium;
ATP
, adenosine triphosphate;
EPA
, Eicosapentaenoic acid; PUFAs, Polyunsatu-
rated fatty acids;
PE
, phosphatidyl ethanolamine;
PEG
, poly(ethylene glycol);
AmpB
, amphotericin B; dauno, daunorubicin; dox, doxorubicin HCl;
cisPT
, cisplatin; PGE1,
prostaglandin E1; CL, cardiolipin;
Ch
, cholesterol;
PC
, phosphatidyl choline;
PG
, phosphatidyl glycerol [
1
-
7
,
103
-
135
]
β
