Environmental Engineering Reference
In-Depth Information
Disease/cell
targeted/agent
Immunological
response
Liposome type
Formulation
Agent transported
Mechanism
References
Erythrocyte
membrane like
polymeric NPs
Sub-100-nm polymeric particles are
coated with RBC membrane derived ves-
icles to mimic complex surface chemistry
of erythrocyte membrane. Synthetic
zwitterionic materials such as poly
(carboxybetaine) and poly(sulfobetaine)
have been proposed as alternatives to
PEG because of their strong hydration
that is highly resistant to nonspecific pro-
tein adsorption
Doxorubicin
Provides a bilayered medium for transmembrane
protein anchorage and avoids chemical modifications
that could compromise the integrity and functionali-
ties of target proteins. The drug release is gradual
Acute myeloid
leukemia
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]
Oligomannose
coated lipo-
somes (OML)
Dipalmitoylphosphatidylethanolcholine,
cholesterol and mannosetriose-
dipalmitoylphosphatidylethathanolamine
at 10:10:1
(1) Ovalbumin A
(2) Soluble leish-
manial antigen, sol-
uble lysates of
Toxoplasmsa gondii
,
Trypanosoma brucei
gambiense
,
Babesia
rodhaini
or
Neospora caninum
(2) Soluble leish-
manial antigen, sol-
uble lysates
of
Toxoplasmsa
gondii
,
Trypanosoma brucei
gambiense
,
Babesia
rodhaini
or
Neospora caninum
(4) Cryj1 allergen
OMLs are recognized by Mannose binding lectin
receptors (MBLRs) on Antigen presenting Cell
(APC) and enter into cell. After antigen processing
and presentation, they are flagged by Class I and
Class II MHC molecules, OMLs, activate, mature
APC with enhanced expression of costimulatory like
CD40, CD80, CD86 and MHC II and
proinflammatory cytokines, IL1, IL6. OMLs coated
with allergen induce IFN gamma by Th1 cells
inhibits Th2 response. Cry J entrapped OML pre-
vents elevation of serum IgE level, control Type I
allergy
Infection, cancer,
allergy
Induce antigen-
specific CD8+
Cytotoxic T Lym-
phocytes (CTLs),
stimulation of
invariant natural
killer T cells lead-
ing to strong cel-
lular immunity
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65
,
113
-
119
]
