Environmental Engineering Reference
In-Depth Information
Table 9.1 Different liposomal formulations as carriers of nanomedicine
Disease/cell
targeted/agent
Immunological
response
Liposome type
Formulation
Agent transported
Mechanism
References
Polymer core
lipid shell
Polymer
PLGA-lecithin-PEG
core-shell NPs
(1) Docetaxel
Doxil/Caelyx and
Genexol-PM
(2) Clotrimazole
(3) Doxorubicin
(4) Paclitaxel
(5) Fluorouracil
Lipid monolayer acts as a molecular fence and con-
tributes to keep the drug molecules in the hydro-
phobic core, and water out of the core which would
hydrolyze the PLGA polymer and increase erosion
and drug release
The mechanism of drug release from a polymeric
core is typically bulk or surface erosion, or in some
cases a combination of both
(1) Hela and HEpG2
(2) Fungal infections
in rats
(3-5) Metastatic
breast cancer, head
and neck cancer, gas-
tric cancer, hormone-
refractory prostate
cancer, and non-small-
cell lung cancer
Controlled drug
release and physi-
cal stability in PBS
and plasma. NPs
well tolerated by
human cell line
models, HeLa and
HepG2
[
103
-
107
]
Hollow core
shell type lipid
polymer lipid
NPs
Polymer: poly(lactic-
co
-glycolic
acid) dilinoleoylphosphatidylcholine
1,2-ditetradecanoyl-
sn
-glycero-3-
phosphoethanolamine-
N
-diethylenetria-
minepentaacetic acid poly
(2-methyloxazoline)-block-poly
(dimethylsiloxan)-block-poly
(2-methyloxazoline)
Lipids: Stearic acid
Lecithin decanoic acid triolein
Doxorubicin and
combretastatin pac-
litaxel indium
111 and yttrium
90 Fluoroquinolone
antibiotics, cisplatin,
and gemcitabine
PEGs are being employed in long-circulating NPs
formulation, thereby reducing plasma protein
adsorption, macrophage uptake, and particle aggre-
gation, while increasing circulation time. Antibodies/
other targeting ligands are attached to the surface of
nanoliposomes by using various covalent and
noncovalent coupling techniques
First, the phospholipid forms a bilayer in aqueous
solution and attaches to the polystyrene particle sur-
face by adsorption to form homodispersed and stable
phospholipid vesicle-covered particles. Second, after
bilayer attachment, hydrophobic attractions between
the polystyrene surface and hydrocarbon chain of the
phospholipid bilayer collapse the bilayer structure
Adenocarcinoma,
breast cancer, resistant
cancers.
Complement sys-
tem activation,
plasma/serum pro-
tein binding, and
coagulation cas-
cade activation
[
108
-
110
]
