Biomedical Engineering Reference
In-Depth Information
signii cant decrease in endothelial tubular formation. Secondly, targeting
ligands conjugated with that of heparin derivatives have been used for
the receptor mediated delivery of anticancer drug. Heparin-folic acid-
retinoic acid (HFR) bioconjugates are being used for treatment of cancer
cells [136].
Recently, a pH responsive drug carrier is developed, based on chondrio-
tin sulfate functionalized mesostructured silica nanoparticles (NMChS-
MSNs) i.e., the amidation between NMChS macromer and amino group
functionalized MSNs. h ese nanoparticles were spherical in shape with a
mean diameter of about 74nm. A well known anti-cancer drug, Doxorubicin
hydrochloride (DOX) was loaded into the channels of NMChS-MSNs
through the electrostatic interactions between drug and matrix. As a result,
drug release rate was pH dependent and it increases with the decrease in
pH.
In vitro
cytotoxicity test also proves that these nanoparticles are highly
biocompatible and can be used as a drug carrier. h e above experiment
proves that these chondriotin sulfate mesostructured functionalized silica
nanoparticles are good platforms for pH dependent controlled drug deliv-
ery systems for cancer therapy [137].
Pancreatic cancer is a highly lethal disease with a 5-year survival rate
less than 5% due to the lack of an early diagnosis method and ef ective
therapy. Recently, a multifunctional nanoimmunoliposome with high
loading of ultra small super paramagnetic iron oxides (USPIOs) and
doxorubicin (DOX) was prepared by transient binding and reverse-phase
evaporation method and then conjugated with anti-mesothelin mono-
clonal antibody by post-insertion method to target anti-mesothelin-
overexpressed pancreatic cancer cells.
In vivo studies have shown that,
comparing with FD (free DOX) and PLDU, M-PLDU possessed higher
inhibitory ef ect on tumour growth and the tissue distribution assay fur-
ther proved that M-PLDUs get selectively accumulated in the tumour
xenograt [138].
A novel magnetic nanoparticle for drug carrier has been recently dis-
covered for the enhanced cancer chemotherapy. Magnetic nanoparti-
cles loaded with antitumor drugs in presence of external magnetic i eld
resulted in improvement in cancer treatment. In this experiment, DOX-
PGMNPs nanoparticles were synthesized and cytotoxicity was assessed
in
vitro
. Along with this, intravenous administration of DOX-PGMNPs to
H22 hepatoma cell tumour bearing mice, biodistribution of DOX was also
measured in dif erent tissues [139].
One of the nanoparticle poly-(D,L-lactide-co-glycolide)/montmo-
rillonite were decorated by Trastuzumab, an epidermal growth fac-
tor receptor-2(HER-2) antibody and was being used for targeted breast
