Biomedical Engineering Reference
In-Depth Information
cancer chemotherapy with paclitaxel as a model anticancer drug. h ese
nanoparticles were prepared by solvent extraction/evaporation method.
Internalization of the coumarin-6-loaded PLGA/MMT NPs with or with-
out the antibody decoration by both of Caco-2 colon adeno carcinoma cells
and SK-BR-3 breast
cancer
cells were visualized by confocal laser scanning
microscopy and quantitatively analyzed, which shows that the antibody
decoration achieved signii cantly higher cellular uptake of the NPs to treat
breast cancer [140].
Development of functionalized super paramagnetic iron oxide nanopar-
ticles were being reported to interact with human cancer cells. h e capacity
of interaction of the cells with these nanoparticles as well as cytotoxicity
was evaluated in human melanoma cells. Out of the four formulations
of nanoparticles, only the polyvinyl alcohol super magnetic iron oxide
nanoparticles interact with cells and cytotoxicity was negative in human
melanoma cells [141].
14.5 Conclusion
Nanotechnology is globally emerging technology for targeted drug deliv-
ery. Due to some disadvantages related to the unconventional strategies,
such as larger amount of drug consumption by patients, more time in
recovering lead to the more use of dif erent kinds of nanoparticles as drug
carriers. h ey basically act by crossing the biological barriers and target-
ing the site. Nanoparticles such as solid lipid nanoparticles, polymeric
nanoparticles, liposomes, mesoporous silica nanoparticles are being used
for treatment of various types of diseases. Several carriers based drug deliv-
ery system incorporating anti-TB drugs have been developed for target site
action. Nanoparticles encapsulating anticancer drugs such as doxorubicin
have been also developed for treatment of various types of cancers such as
prostate cancer, breast cancer, pancreatic cancer and lung cancer. All these
developments in drug delivery reports have resulted in signii cant merits
such as improved drug bioavailability, reducing dosing frequency, versatil-
ity of routes of administration and long term stability which become the
basis of better management of diseases. Recently, aerosol vaccines are being
in progress for drug delivery. Besides having so many advantages, some
of the toxicological issues related to understanding the fate of nanocarri-
ers, polymeric constituents in the body as well as elimination of residual
should be deleted. harmful residual organic solvents have to be resolved.
Future research on vectorized delivery system of drug has been focussed
for large amount of drug delivery and for better results.
