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(a)
O
O
P
O
N
O
N
O
O
N
O
O
-
Gd
O
N
Na
+
O
N
O
O
O
O
O
(b)
NEt
2
HS
N
O
Tc
S
S
N
S
NEt
2
(c)
Sulfonate groups
improve aqueous
solubility
Na
+
O
-
O
S
O
Na
+
O
O
-
O
O
-
S
S
O
O
O
N
N
+
O
S
O
O
Na
+
O
-
O
NHS ester is a
pre-activated
acide for reaction
with amine
O
N
O
fIGure 16.16
Structures of (a) GdDOTA-DSPE, (b)
99m
Tc(V)BMEDA [67], and (c) IRDye.
OH
O
H
H
H
H
fIGure 16.17
Structure of 5-Ī²-cholanic acid.
peptide that interferes with the RGD-integrin interaction 30 min. prior to injection of the labelled ferritin results in decreased
ferritin uptake by the tumour.
Ex vivo
images of organs from animals sacrificed at 40 h show a lower amount in the animal
that was treated with the blocking peptide. The authors conclude that accumulation in the tumour is due to both RGD target-
ing and the EPR effect.
Changes in the lymph nodes are closely related to tumour metastasis. Sentinel lymph node (SNL) imaging is important
because it can give information on the metastatic status of tumours, which can be useful for tumour staging and therapeutic
decision making. In this work, NIR dye ZW800 (FigureĀ 16.18a), Gd
3+
, and
64
Cu were incorporated into 60 nm mesoporous
