Resting-State Functional Connectivity in Animal Models: Modulations by Exsanguination - Dynamic Brain Imaging - page 256

Table 12.1
Average correlation coefficients in stereotaxically defined anatomical regions of
interest after cross correlation with 6 different seed voxels chosen from vari-
ous spatial locations within the cerebral cortex region of interest from a typical
rat (rat2)

Cerebral cortex Caudate putamen Hippocampus Thalamus

Normal Exsanguinated Normal Exsanguinated Normal Exsanguinated Normal Exsanguinated

0.08 0.28 0.05 0.18 0.02 0.13 0.05 0.22

0.07 0.33 0.01 0.24 − 0.03 0.14 0.02 0.28

0.09 0.19 0.03 0.17 − 0.02 0.07 0.01 0.11

0.13 0.24 0.04 0.14 0.01 0.13 0.02 0.19

0.10 0.29 0.06 0.17 0.02 0.14 0.05 0.23

0.10 0.28 0.04 0.18 0.00 0.14 0.04 0.24

Table 12.2
Grand mean of the correlation coefficients in different anatomical regions of interest
over all rats. The signal time series from six seed voxels in various spatial locations
within the cerebral cortex region of interest was cross-correlated with all voxels
from the cerebral cortex and other anatomical regions of interest namely caudate
putamen, hippocampus and thalamus. Significance was tested considering 6 rats,
which were “successful” under the hypothesis that exsanguination increases the
average correlation coefficient in the cerebral cortex

Animal Cerebral cortex Caudate putamen Hippocampus Thalamus

Normal Exsanguinated Normal Exsanguinated Normal Exsanguinated Normal Exsanguinated

Rat1 0.043 0.077 0.018 0.050 − 0.013 − 0.042 0.033 0.044

Rat2 0.098 0.266 0.038 0.136 0.001 0.128 0.027 0.212

−

Rat3 0.071 0.142 0.035 0.038 0.043 0.031 0.095 0.055

Rat4 0.080 0.330 0.051 0.243 0.006 0.146 0.095 0.262

Rat5 0.056 0.049 − 0.030 0.036 − 0.021 − 0.002 0.036 0.042

Rat6 0.075 0.352 0.038 0.236 0.026 0.131 0.035 0.278

Rat7 0.083 0.271 0.020 0.216 0.003 0.125 0.021 0.194

Mean 0.07 0.21 0.01 0.14 0.01 0.07 0.05 0.16

SD 0.13 0.12 0.04 0.10 0.02 0.08 0.03 0.11

Note: P < 0. 001 cortex with respect to hippocampus during normal condition. P < 0. 0003 cortex with respect to

hippocampus during exsanguinated condition. P < 0. 008 cortex with respect to caudate putamen during normal

condition. P < 0. 001 cortex with respect to caudate putamen during exsanguinated condition. P < 0. 19 cortex with

respect to thalamus during normal condition. P < 0. 0004 cortex with respect to thalamus during exsanguinated

condition.