Myocardial Infarction: Cardioprotection by Erythropoietin - Tissue-Protective Cytokines: Methods and Protocols - page 265

Olea ( 29 ) 2006 Sheep rhEPO 3,000 i.v. Right before Rep,

then daily for 3
days

90 At 10 weeks:

MI size p = NS

LVEDP ↑ p < 0.03

LV volume ↑ p < 0.05

Septum thickening ↓ p < 0.04

Liu ( 30 ) 2006 Rat rhEPO 5,000 i.p. 24 h before Isch 30 At 24 h: MI size ↓ p < 0.01

Gao ( 31 ) 2007 Rat Darbepoetin 2, 7,

11, 30 mg/kg i.v.

Start Isch, 1 or 24 h
after Rep

30 At 3 h:

MI size ↓ p < 0.05-0.01

Cardiac reserve ↑ p < 0.05-0.001

CM apoptosis ↓ p < 0.05

Baker ( 32 ) 2007 Rat Darbepoetin

2.5 mg/kg i.v.

15 min before Isch or
start Rep, or 24 h
post Rep

30 At 2 h:

MI size ↓ p < 0.05

cTnI ↓ p < 0.05

Toma ( 33 ) 2007 Pig Darbepoetin

30 mg/kg i.v.

At Rep 60 At 2 weeks:

MI size p = NS

Fibrosis ↓ p < 0.02

Capillaries ↓ p < 0.003

LV wall motion ↑ p < 0.05

Singh ( 34 ) 2007 Rat rhEPO 5,000

intra-right atrium

15 min before VF or
at 10 min VF, start
of chest
compression

10 min cardiac
arrest with VF

At resuscitation:

Aortic press ↑ p < 0.05

Cardiac index ↑ p < 0.05 only

after 10 min VF

Boucher ( 35 ) 2008 Rat Darbepoetin

30 mg/kg i.v.

Start of Isch 30 At 3 days:

MI size

↓ p < 0.05

CM apoptosis ↓ p < 0.05

LVEF echo ↑ p < 0.05

Prunier ( 36 ) 2009 Rat Darbepoetin 5,000,

or 5,000 and 300
(~1.5 mg/kg) i.p.

Start Rep+-once-a-
week

45 At 8 weeks:

MI size ↓ p < 0.05

Thrombosis p = NS

(continued)