Biology Reference
In-Depth Information
Table 2
(continued)
Time of treatment
End-points
First author
and references
EPO, type and
doses (IU/kg)
Duration of
occlusion (min)
Date
Species
Relative to Isch/Rep
End-points
Outcomes
Hirata (
23
)
2005
Dog
EPO 100 to 1,000
i.v.
10 min before Rep
90
At 6 h:
MI size
↓
p
< 0.05
VF
↓
p
< 0.05
CM apoptosis
↓
p
< 0.05
Xu (
24
)
2005
Rat
rhEPO 3,000 i.p.
24 h before Isch
30
At 2 h:
MI size
↓
p
< 0.001
Hsp70
↑
p
< 0.001
NF-kB
↓
p
< 0.001
Bullard (
25
)
2005
Rat
EPO 5,000 i.v.
Right before Rep
40
At 24 h: MI size
↓
p
< 0.05
Kristensen (
26
)
2005
Pig
EPO 500 i.v.
1.5 h or 24 h before
Isch
45
At 2.5 h: MI size
p
= NS
Liu (
27
)
2006
Rat
rhEPO 5,000 i.v.
24 h before Isch
30
At 3 h:
MI size
↓
p
< 0.001
MPO
↓
p
< 0.01
NF-kB, Ap-1
↓
p
< 0.05
TNFa
↓
p
< 0.01
Nishihara (
28
)
2006
Rat
EPO 5,000 i.v.
5 min before Rep
20
At 2 h:
MI size
↓
p
< 0.05
Akt
phosphorylation
↓
p
< 0.05
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