Biology Reference
In-Depth Information
Table 2
(continued)
Time of treatment
End-points
First author
and references
EPO, type and
doses (IU/kg)
Duration of
occlusion (min)
Date
Species
Relative to Isch/Rep
End-points
Outcomes
Shan (
37
)
2008
Mouse
EPO 1,000
Start Rep
45
At 4 h:
MI size
↓
p
< 0.05
LVEF
↑
p
< 0.05
CM apoptosis
↓
p
< 0.05
Doue (
38
)
2008
Rat
EPO 200 i.v.
Start Rep
20
At 30 min:
Annexin V area
↓
p
< 0.001
At 2 and 4 weeks:
LVEDd
↓
p
< 0.01
LV FS
↑
p
< 0.01
Huang (
39
)
2008
Mouse
EPO 1,000, 3,000,
5,000 i.v.
3 min after resuscita-
tion from asphyxia-
induced cardiac
arrest
6.5 or 9.5
At 3 days:
Survival
↑
p
< 0.003
d
P
/d
t
↑
p
< 0.03 (only at
EPO 5,000
U/kg)
Burger (
40
)
2009
Mouse
rhEPO 2,500 i.v.
24 h before Isch or
5 min after Isch
start
45
At 3 or 6 h:
MI size
↓
p
< 0.05
CM apoptosis
↓
p
< 0.05 (no
effect of EPO in
HO-1−/− mice)
Search WWH ::
Custom Search