Marine n-3 Polyunsaturated Fatty Acids and Cellular Adhesion Molecules in Healthy Subjects and in Patients with Ischaemic Heart Disease - Adhesion Molecules - page 453

Table 1 Clinical trial investigating the effect of supplementing marine n-3 PUFA on levels of soluble cellular adhesion molecules (sCAMs)

Reference Design, population, intervention time Intervention sCAMs Signii cant results ( Ø or )

Healthy subjects

Eschen et al . 2004 RCT, double-blind Gr. 1: Placebo sICAM-1 Gr. 3:

N = 60 Gr. 2: 2.0 g EPA + DHA sP-selectin sP-selectin Ø

12 wk Gr. 3: 6.6 g EPA + DHA sVCAM-1

Miles et al . 2001 RCT, double-blind Gr. 1: 1.2 g EPA + DHA sVCAM-1 Gr. 1:

(n = 16) males < 40 yr, Gr. 2: Placebo sE-selectin sE-selectin (males < 40 yr)

(n = 12) subjects > 55yr sVCAM-1 sVCAM-1 Ø (subjects > 55 yr)

12 wk

h ies et al . 2001 RCT, double-blind 6 groups, dif erent mix of FA: sICAM-1 Gr. 6:

(n = 46) age 55-70 yr Gr. 5: 0.7 g DHA sE-selectin sVCAM-1 Ø

12 wk. Gr. 6: 1.0 g EPA + DHA sVCAM-1 sE-selectin Ø

Cazzola et al . 2007 RCT, double-blind Gr. 1: Placebo sICAM-1 Gr. 4:

(n = 93) males, 18-42 yr Gr. 2: 1.35 g EPA + .27 g DHA sE-selectin sE-selectin (males, age 18-42 yr)

(n = 62) males, 53-70 yr Gr. 3: 2.7 g EPA + .54 g DHA sVCAM-1

12 wk Gr. 4: 4.05 g EPA + .81 g DHA

Patients at increased risk of IHD

Hjerkinn et al . 2005 RCT, double-blind, factorial 2 × 2. ± 2.4 g EPA + DHA sICAM-1 n-3 PUFA group and diet group:

(n = 563) long-standing dyslipidaemia. ± Dietary advice sE-selectin sICAM-1 Ø

3 yr sVCAM-1

Abe et al . 1998 A: RCT, double-blind.. A: Gr.1: 4.0 g EPA + DHA sICAM-1 A:

(n = 39) hypertriglyceridaemia Gr. 2: Placebo sE-selectin Gr. 1: sE-selectin