Marine n-3 Polyunsaturated Fatty Acids and Cellular Adhesion Molecules in Healthy Subjects and in Patients with Ischaemic Heart Disease - Adhesion Molecules - page 454

contd...

Seljel ot et al. 1998 RCT, double-blind, factorial 2 × 2 ± 4.8 g EPA + DHA sICAM-1 n-3 PUFA group:

(n = 41) male hyperlipidaemic smokers ± antioxidants sE-selectin E-selectin , sVCAM-1

6 wk sVCAM-1

Patients with CAD

Johansen et al . 1999 Open label Gr. 1: continued 5.1 g EPA + sICAM-1 Gr. 2:

(n = 54) a study extension for a DHA (= control) sE-selectin sE-selectin

subgroup of patients from a larger trial Gr. 2: No prior n-3 PUFA, sVCAM-1 sVCAM-1

4 wk now 5.1 g EPA + DHA.

Patients with a MI

Grundt et al . 2003 RCT, double-blind. Gr. 1: 4.0 g EPA + DHA sICAM-1 No dif erences

(n = 300), 4-6 d at er a MI Gr. 2: Placebo sE-selectin

12 mon

PUFA, polyunsaturated fatty acids; CAD, coronary artery disease; RCT, randomized controlled trial; FO, i sh oil; Gr., group; FA, fatty acids; EPA, eicosapentaenoic acid; DHA,
docosahexaenoic acid; MI, Myocardial infarction; IHD, ischaemic heart disease.