Environmental Engineering Reference
In-Depth Information
Mice.(LDLR/KO)
Carbon.black
120.7.nm
Endotracheal.
dispersion.of.1.mg.
per.animal.per.week.
for.10.weeks.or.
intratracheal.
dispersion.of.air.and.
1.mg.per.animal.per.
week.for.10.weeks..
Diets.were.also.
controlled.for.0.or.
0.51%.cholesterol..
Acute.study.
performed:.animals.
fed.0.51%.cholesterol.
diet.for.3.days.and.a.
single.1.mg/animal.
dose.of.carbon.black.
Aorta/circulatory.
system
Aortic.lipid-rich.lesions.were.
reported.in.mice.receiving.the.
0.51%.diet.with.and.without.
carbon.black.exposure..No.
lesions.in.mice.receiving.the.
0.0%.diet..Greatest.amount.of.
lesions.were.reported.in.
0.51%.group.with.carbon.
black.exposure.
Results.indicate.that.
respiratory.exposure.to.
carbon.black.might.accelerate.
the.development.of.
atherosclerosis.and.be.
associated.with.
cardiovascular.adverse.
effects.
[44]
Rat.aortic.smooth.
muscle.cells
SWCNT
10-15.nm
0.0-0.1.mg/mL.added.
to.cells.and.incubated.
for.periods.of.1,.2.5,.
and.3.5.days
Cytotoxicity
Uniltered.SWCNT.media:.cell.
growth.not.affected.after.1.
day;.decrease.in.cell.growth.at.
2.5.days.for.concentrations.
from.0-0.05.mg/mL;.iltered.
SWCNT.(removal.of.SWCNT.
aggregates):.increase.in.cell.
number.for.concentrations.0-
0.05.mg/mL;.growth.
inhibition.at.0.1.mg/mL.dose.
for.both.iltered.and.uniltered.
SWCNT.
Results.indicate.that.aggregates.
affect.cell.growth,.but.not.
solely.responsible.for.the.
cytotoxicity.
[45]
