Toxicology and Risk Assessment - Nanotechnology and the Environment - page 212

table . (Continued)
effects of nanomaterials or nanoparticles on Mammalian species

size or
diameter species Particle a Category exposure or dose endpoint(s) effect(s) Commentary Ref.

Mouse.
spermatogonial.
stem.cell.line

Nanoscale.silver 15.nm 5,.10,.25,.50,.and.10.

µg/mL

Cytotoxicity;.
mitochondrial.
function,.cell.
morphology,.cell.
membrane.
leakage,.and.cell.
death

Silver.nanoparticles.were.the.
most.cytotoxic.of.the.
compounds.tested..Cytotoxic.
effects.were.dose-dependent.

The.spermatogonial.cell.line.
was.chosen.for.this.study.to.
evaluate.the.toxicity.of.
nanoparticles.on.the.male.
germline..Results.of.this.study.
suggest.that.the.cell.line.is.a.
good.model.

[42]

Human.epithelial.
cells

Nanoparticle.carbon.
black,.Fine.carbon.
black,.Titanium.
dioxide,.
Nanoparticle.TiO 2 .

14.3.nm
260.nm
250.nm
29.nm

31.25-200.µg/mL Cytotoxicity Inlammatory.response The.highly.toxic.nature.and.

reactive.surface.chemistry.of.
the.carbon.black.
nanoparticles.very.likely.
induced.the.type.II.cell.line.to.
release.pro-inlammatory.
mediators.that.can.potentially.
induce.migration.of.
macrophages.

[43]