Environmental Engineering Reference
In-Depth Information
table . (Continued)
effects of nanomaterials or nanoparticles on Mammalian species
size or
diameter
species
Particle
a
Category
exposure or dose
endpoint(s)
effect(s)
Commentary
Ref.
Human.leukemic.
cells
Single-.and.multi-
walled.carbon.
nanotubes;.3.
different.samples.by.
different.synthesis:.
Sample.1.—.
MWCNTs.
(synthesized.by.an.
electric.discharge).
Sample.2.—.50%.
MW.CNTs.+.30%.
SWCNTs.Sample.3.
—.MWCNTs.
(purchased)
Sample.1:.10-50.
nm
Sample.2:.10-40.
nm
Sample.3:.110-
170.nm
25.µg/ml.of.each.of.the.
three.samples
Oxidative.stress/.
cytotoxicity
Cytotoxic.effects.not.observed;.
cell.growth.rate.reduced
With.the.lack.of.cytotoxicity,.
the.decrease.in.cell.growth.
might.be.a.result.of.the.
carbon.nanotubes.affecting.
the.cell.cycle.directly.
[46]
Rat.(in.vivo).
peritoneal.
macrophages.(in.
vitro)
Multi-walled.carbon.
nanotubes.(CNT).
and.ground.CNT
9.7.nm.(CNT).
11.3.nm.(ground.
CNT)
0.5,.2,.or.5.mg/animal.
intratracheally.
instilled.(in.vivo)
Pulmonary.
toxicity:.
inlammatory.
response;.ibrotic.
response
In vivo
.results:.inlammatory.
response.and.dose-dependent.
pulmonary.ibrosis.for.both.
CNT.and.ground.CNT,.effects.
more.pronounced.with.ground.
CNT..
In vitro
.results:.ground.
CNT.increased.macrophage.
production.
Results.indicate.that.multi-wall.
carbon.nanotubes.are.capable.
of.eliciting.inlammatory.and.
ibrotic.response.in.lungs
[31]
