Toxicological Effects of Metal Oxide Nanomaterials - Safety of Nanomaterials along Their Lifecycle - page 182

A clear correlation of specific physicochemical properties with the resulting
biological effects required for QSAR modeling is not available. However, based on
the data obtained for SiO 2 , it is likely that potential adverse effects of metal oxide
nanoparticles can be controlled by modifying their surface properties, which can
be helpful for safer design of engineered nanoparticles for those cases where the
product performance can tolerate such relatively drastic modifications of the nano-
material properties. The data from nanoGEM and NanoCare also provide guidance
for a future nanoparticle risk assessment. Since different physicochemical properties
seem to contribute to nanoparticle toxicity, a testing strategy should encompass mul-
tidisciplinary working with different characterization tools (see Chapter 16). Finally,
the correlations of in vivo and in vitro data presented here suggest that in vitro tests
may allow an initial screening to preselect potentially toxic nanoparticles, a strategy
that eventually should help to minimize the use of animals.
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