Toxicological Effects of Metal Oxide Nanomaterials - Safety of Nanomaterials along Their Lifecycle - page 181

6

SiO 2 naked

4

2

SiO 2
Amino

ZrO 2 Acryl

ZrO PEG

ZrO 2 TODS
ZrO 2 Amino

0

SiO 2 Phosp
AIOOH 1

SiO 2 PEG

BaSO 4 NM22

ZnO
NM110 -2

-4

-6

TiO 2 NM105

-8
-10 -8 -6 -4 -2 0

t[1]

2 4 6 8

R2X[1] = 0,355 R2X[2] = 0,229 Ellipse: Hotelling's T2 (95%)

FIGURE 8.2 Principal component analysis of total in vitro and in vivo data from nanoGEM using the SIMCA-Software (Umetrics AB, Umea,
Sweden). The divergence of the particle attributes is relected by the spatial distance of the data points obtained. Most of the nanoparticle types tested
displayed low or no toxicity and are arranged in a cluster, whereas nanoparticles displaying distinct biological effects are localized separately and distant
from the cluster.