Viremic Hosts
Nymphal Ticks
Uninfected Hosts
Viremic Hosts
FIGURE 5.12  Natural transmission cycle of Colorado tick fever. Transfers of virus are shown with green arrows.
Larval ticks feed on small mammals that can remain viremic for long periods of time and then transmit virus to other
small mammals. Adult ticks, while not important for maintaining the virus in nature may then bite nonreservoir hosts
such as deer or man. Adult ticks lay eggs to produce the next generation of larval ticks, but no transovarial transmission
of virus occurs. Adapted from Bowen (1988) Figure 4.
particles suitable for genetic studies of the receptor-binding protein.
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