Neurological Disorders

Angelman Syndrome: Proteomics Analysis of an UBE3A Knockout Mouse and Its Implications (Proteomic Analysis in Neurological Disorders) Part 3

Validation of 2-D DIGE/MS results by Western blot analysis Western blot was conducted to validate the differentially expressed proteins that were identified in 2-D DIGE/MS. In the cerebellum, three proteins, including SOD2, CaBP and Mash1, were down-regulated in Ube3a knockout mice [Figure 5], while Hsp70, NSF and NeuroD were accumulated in knockout mice [Figure 6]. […]

Angelman Syndrome: Proteomics Analysis of an UBE3A Knockout Mouse and Its Implications (Proteomic Analysis in Neurological Disorders) Part 4

Discussion When Ube3a was first identified as an E3 ligase, little was known about its targeting substrates besides p53 (1). However, as techniques improved over the years, additional substrates of Ube3a were identified [Table 6]. Gene / Protein Function Reference 1 Src Family of Tyrosine Kinase Blk Regulators of cytoskeletal organization, cell-cell contact, cell-matrix adhesion, […]

Migraine: Molecular Basis and Herbal Medicine (Migraine and the Use of Herbal Medicine as an Alternative Treatment) (Neurological Disorders) Part 1

Introduction Migraine is a common and disabling brain disorder with no single characteristic which could be used for a definite diagnosis. Usually a combination of different presentations is used as diagnostic criteria which may lead to a challenging feature of under- or misdiagnosis and also under-treatment. Diagnostic criteria for migraine usually emphasize on specificity compared […]

Migraine: Molecular Basis and Herbal Medicine (Migraine and the Use of Herbal Medicine as an Alternative Treatment) (Neurological Disorders) Part 2

Practical considerations There are some notable issues about mentioned biomarkers: (i) several of these biomarkers have potential interactions with others and have influences on concentration of other biomarkers. For example, melatonin as an imperative antioxidant is considered to be scavenger of nitric oxide and its toxic metabolite peroxynitrite (ONOO-) from body. Additionally, melatonin can indirectly […]

Migraine: Molecular Basis and Herbal Medicine (Migraine and the Use of Herbal Medicine as an Alternative Treatment) (Neurological Disorders) Part 3

Herbal medicine History Before the advent of modern synthetic drugs, herbs were considered as first choice for treatment of human diseases. In spite of the fact that using herbs has been diminished in modern medicine, fortunately, there is a growing trend, particularly in migraine disorder. There have been few studies examining herbal remedy effectiveness and […]

Substance Dependence as a Neurological Disorder (Neuropsychiatry of Drug and Alcohol Dependence) Part 1

Introduction Traditionally, explanations of drug addiction adhered to a moralistic perspective. This perception, still held by many individuals and policy makers, suggests addiction is a problem to be addressed through the criminal justice system (Brown, 2011; Leshner, 1997). However, this approach has yielded little success in addressing the problem (Lee et al., 2010) and may […]

Substance Dependence as a Neurological Disorder (Neuropsychiatry of Drug and Alcohol Dependence) Part 2

Executive function, treatment, recovery and psychostimulant dependence Significant variability exists within the literature regarding the persistence of executive deficits (Chang et al., 2002; Hoffman et al., 2006) and structural and functional differences (Chang et al., 2002; Kim et al., 2005) during abstinence from psychostimulant dependence. While this literature generally supports the persistence of executive deficits […]

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