Laboratory Values of Clinical Importance (Rheumatology) Part 5

TABLE A-4

VITAMINS AND SELECTED TRACE MINERALS

REFERENCE RANGE

SPECIMEN

ANALYTEa

SI UNITS

CONVENTIONAL UNITS

Aluminum

S

<0.2 μmol/L

<5.41 μg/L

U, random

0.19-1.11 μμmol/L

5-30 μg/L

Arsenic

WB

0.03-0.31 μmol/L

2-23 μg/L

U, 24 h

0.07-0.67 μmol/d

5-50 μg/d

Cadmium

WB

<44.5 nmol/L

<5.0 μg/L

Coenzyme Q10 (ubiquinone)

P

433-1532 μg/L

433-1532 μg/L

B carotene

S

0.07-1.43 μmol/L

4-77 μg/dL

Copper

S

11-22 ^moi/L

70-140 μg/dL

U, 24 h


<0.95 μmol/d

<60 μg/d

Folic acid

RC

340-1020 nmol/L cells

150-450 ng/mL cells

Folic acid

S

12.2-40.8 nmol/L

5.4-18.0 ng/mL

Lead (adult)

S

<0.5 μmol/L

<10 μg/dL

Mercury

WB

3.0-294 nmol/L

0.6-59 μg/L

U, 24 h

<99.8 nmol/L

<20 μg/L

Selenium

S

0.8-2.0 μmol/L

63-160 μg/L

Vitamin A

S

0.7-3.5 μmol/L

20-100 μg/dL

Vitamin B1 (thiamine)

S

0-75 nmol/L

0-2 μg/dL

Vitamin B2 (riboflavin)

S

106-638 nmol/L

4-24 μg/dL

Vitamin B6

P

20-121 nmol/L

5-30 ng/mL

Vitamin B12

S

206-735 pmol/L

279-996 pg/mL

Vitamin C (ascorbic acid)

S

23-57 μmol/L

0.4-1.0 mg/dL

Vitamin D3, 1,25-dihydroxy

S

60-108 pmol/L

25-45 pg/mL

Vitamin D3, 25-hydroxy

P

Summer

37.4-200 nmol/L

15-80 ng/mL

Winter

34.9-105 nmol/L

14-42 ng/mL

Vitamin E

S

12-42 μmol/L

5-18 μg/mL

Vitamin K

S

0.29-2.64 nmol/L

0.13-1.19 ng/mL

Zinc

S

11.5-18.4 μmol/L

75-120 μg/dL

aP, plasma; RC, red cells; S, serum; WB, whole blood; U, urine.

TABLE A-5 CLASSIFICATION OF LDL, TOTAL, AND HDL CHOLESTEROL

LDL Cholesterol, mg/dL (mmol/L)

<70 (<1.81)

Therapeutic option for very high risk patients

<100 (<2.59)

Optimal

100-129 (2.59-3.34)

Near optimal/above optimal

130-159 (3.36-4.11)

Borderline high

160-189 (4.14-4.89)

High

>190 (>4.91)

Very high

Total Cholesterol, mg/dL (mmol/L)

<200 (<5.17)

Desirable

200-239 (5.17-6.18)

Borderline high

>240 (>6.21)

High

HDL Cholesterol, mg/dL (mmol/L)

<40 (<1.03)

Low

>60 (>1.55)

High

Note: LDL, low-density lipoprotein; HDL, high-density lipoprotein

TABLE A-6

CEREBROSPINAL FLUID (CSF)a

REFERENCE RANGE

CONSTITUENT

SI UNITS

CONVENTIONAL UNITS

Osmolarity

292-297 mmol/kg water

292-297 mosmol/L

Electrolytes

Sodium

137-145 mmol/L

137-145 meq/L

Potassium

2.7-3.9 mmol/L

2.7-3.9 meq/L

Calcium

1.0-1.5 mmol/L

2.1-3.0 meq/L

Magnesium

1.0-1.2 mmol/L

2.0-2.5 meq/L

Chloride

116-122 mmol/L

116-122 meq/L

CO2 content

20-24 mmol/L

20-24 meq/L

P CO2

6-7 kPa

45-49 mmHg

pH 2

7.31-7.34

Glucose

2.22-3.89 mmol/L

40-70 mg/dL

Lactate

1-2 mmol/L

10-20 mg/dL

Total protein

Lumbar

0.15-0.5 g/L

15-50 mg/dL

Cisternal

0.15-0.25 g/L

15-25 mg/dL

Ventricular

0.06-0.15 g/L

6-15 mg/dL

Albumin

0.066-0.442 g/L

6.6-44.2 mg/dL

IgG

0.009-0.057 g/L

0.9-5.7 mg/dL

IgG indexh

0.29-0.59

Oligoclonal bands

<2 bands not present in matched serum sample

Ammonia

15-47 μmol/L

25-80 μg/dL

Creatinine

44-168 μmol/L

0.5-1.9 mg/dL

Myelin basic protein

<4 μg/L

CSF pressure

50-180 mmH2O

CSF volume (adult)

~150 mL

Red blood cells

0

0

Leukocytes

Total

0-5 mononuclear cells per μL

0-5 mononuclear cells per mm3

Differential

Lymphocytes

60-70%

Monocytes

30-50%

Neutrophils

None

aSince cerebrospinal fluid concentrations are equilibrium values, measurements of the same parameters in blood plasma obtained at the same time are recommended. However, there is a time lag in attainment of equilibrium, and cerebrospinal levels of plasma constituents that can fluctuate rapidly (such as plasma glucose) may not achieve stable values until after a significant lag phase.

hIgG index = CSF IgG(mg/dL) X serum albumin(g/dL)/Serum IgG(g/dL) X CSF albumin(mg/dL).

TABLE A-7

URINE ANALYSIS

REFERENCE RANGE

SI UNITS

CONVENTIONAL UNITS

Acidity, titratable

20-40 mmol/d

20-40 meq/d

Ammonia

30-50 mmol/d

30-50 meq/d

Amylase

4-400 U/L

Amylase/creatinine clearance ratio [(Clam/Clcr) X 100]

1-5

1-5

Calcium (10 meq/d or 200 mg/d dietary calcium)

<7.5 mmol/d

<300 mg/d

Creatine, as creatinine

Female

<760 μmol/d

<100 mg/d

Male

<380 μmol/d

<50 mg/d

Creatinine

8.8-14 mmol/d

1.0-1.6 g/d

Eosinophils

<100,000 eosinophils/L

<100 eosinophils/mL

Glucose (glucose oxidase method)

0.3-1.7 mmol/d

50-300 mg/d

5-Hydroxyindoleacetic acid (5-HIAA)

10-47 μmol/d

2-9 mg/d

Iodine, spot urine WHO classification of iodine deficiency

Not iodine deficient

>100 μg/L

>100 μg/L

Mild iodine deficiency

50-100 μg/L

50-100 μg/L

Moderate iodine deficiency

20-49 μg/L

20-49 μg/L

Severe iodine deficiency

<20 μg/L

<20 μg/L

Microalbumin

Normal

0.0-0.03 g/d

0-30 mg/d

Microalbuminuria

0.03-0.30 g/d

30-300 mg/d

Clinical albuminuria

>0.3 g/d

>300 mg/d

Microalbumin/creatinine ratio

Normal

0-3.4 g/mol creatinine

0-30 μg/mg creatinine

Microalbuminuria

3.4-34 g/mol creatinine

30-300 μg/mg creatinine

Clinical albuminuria

>34 g/mol creatinine

>300 μg/mg creatinine

Oxalate

Male

80-500 μmol/d

7-44 mg/d

Female

45-350 μmol/d

4-31 mg/d

pH

5.0-9.0

5.0-9.0

Phosphate (phosphorus) (varies with intake)

12.9-42.0 mmol/d

400-1300 mg/d

Potassium (varies with intake)

25-100 mmol/d

25-100 meq/d

Protein

<0.15 g/d

<150 mg/d

Sediment

Red blood cells

0-2/high power field

White blood cells

0-2/high power field

Bacteria

None

Crystals

None

Bladder cells

None

Squamous cells

None

Tubular cells

None

Broad casts

None

Epithelial cell casts

None

Granular casts

None

Hyaline casts

0-5/low power field

Red blood cell casts

None

Waxy casts

None

White cell casts

None

Sodium (varies with intake)

100-260 mmol/d

100-260 meq/d

Specific gravity

1.001-1.035

1.001-1.035

Urea nitrogen

214-607 mmol/d

6-17 g/d

Uric acid (normal diet)

1.49-4.76 mmol/d

250-800 mg/d

Note: WHO, World Health Organization.

TABLE A-8

DIFFERENTIAL NUCLEATED CELL COUNTS OF BONE MARROW ASPIRATESa

OBSERVED RANGE, %

95% CONFIDENCE INTERVALS, %

MEAN, %

Blast cells

0-3.2

0-3.0

1.4

Promyelocytes

3.6-13.2

3.2-12.4

7.8

Neutrophil myelocytes

4-21.4

3.7-10.0

7.6

Eosinophil myelocytes

0-5.0

0-2.8

1.3

Metamyelocytes

1-7.0

2.3-5.9

4.1

Neutrophils

Males

21.0-45.6

21.9-42.3

32.1

Females

29.6-46.6

28.8-45.9

37.4

Eosinophils

0.4-4.2

0.3-4.2

2.2

Eosinophils plus eosinophil

0.9-7.4

0.7-6.3

3.5

myelocytes

Basophils

0-0.8

0-0.4

0.1

Erythroblasts

Male

18.0-39.4

16.2-40.1

28.1

Females

14.0-31.8

13.0-32.0

22.5

Lymphocytes

4.6-22.6

6.0-20.0

13.1

Plasma cells

0-1.4

0-1.2

0.6

Monocytes

0-3.2

0-2.6

1.3

Macrophages

0-1.8

0-1.3

0.4

M:E ratio

Males

1.1-4.0

1.1-4.1

2.1

Females

1.6-5.4

1.6-5.2

2.8

aBased on bone marrow aspirate from 50 healthy volunteers (30 men, 20 women).

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