Immunological Response to Experimental Intracerebral Hemorrhage: Morphological Assessments - Animal Models of Acute Neurological Injuries: Injury and Mechanistic Assessments - page 599

Matrix metalloprotease-related genes (mRNA)
MMP2 ↑

C - - +++ - ( 8 )

MMP3 ↑ B

C

- -

+++

- - -

-

- ( 8, 13 )

MMP7 ↑ C ++++ - + - ( 8 )

MMP9 ↑ B

C

-
+++

- - - -

+++

- ( 8, 13 )

MMP12 ↑ B

C

- +

-

++++ - ++

++++

- ( 8, 13 )

TIMP-1 ↑ B

C

+ ++

++

+++ - ++

+++

- ( 8, 13 )

TIMP-2 ↓ C ++ - ++ - ( 8 )

TIMP-3 ↓ C - - ++ - ( 8 )

Complement system
C9 (IH (ABC); WB) B ++ ++ ( 6 )

C3 (IF) B + + ++ +++ + ( 3 )

C3d (IH (ABC); WB) B + +++ ( 6 )

Clusterin (IH (ABC); WB) B ++ ( 6 )

CR2 receptor for C3d (IF) B + ++ +++ ++ + ( 3 )

CR3 (mRNA) microglia activation B + + +++ ++ ( 13 )

ADAPTIVE CELLULAR IMMUNE RESPONSE
CD4+ (CD3+, CD45 hi ) FC B - ++ ( 4 )

CD 8 alpha FC
IP

B
B

- - - +++ ++ - + ( 4, 14 )

CD 8 alpha C - - - - +++ +++ ++ + + ( 12 )

NF kappa B (IP) B + ++ +++ ++ + ( 3 )

Apoptosis
TUNEL+ cell counts Apoptag in situ kit B + + ++ +++ ++ ++ + + + ( 12 )

TUNEL + cell counts Apoptag in situ kit C + + ++ ++ +++ +++ +++ ++ + ( 12 )

Astrocytosis
GFAP (mRNA) B + ++ +++ +++ ( 13 )

(continued)