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Fig. 5. Sample result of voxel-based morphometry (VBM). Gray matter density difference between healthy controls (HCs)
and patients with Alzheimer's disease (AD) covaried for age, gender, education, and handedness, where highlighted regions
correspond to signifi cant gray matter loss in AD (corrected p £ 0.001 for diagnosis effect of HC-AD). SPM (see Table 3 ) was used
in this analysis. (From ref. ( 13 ) : Reprinted with permission from Elsevier).
Fig. 6. Sample result of surface-based morphometry (SBM). Cortical thickness difference between healthy controls (HCs)
and patients with Alzheimer's disease (AD) covaried for age, gender, education, handedness, and intracranial volume,
where red and green regions indicate more cortical gray matter loss in AD. FreeSurfer and SurfStat (see Table 3 ) were used
in this analysis. (From ref. ( 14 ) : Reprinted with permission from Springer).
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