Calcium Phosphate and Calcium Phosphosilicate Mediated Drug Delivery and Imaging - Intracellular Delivery: Fundamentals and Applications - page 725

Surface decoration/adsorption
System

Active agent Remarks Reference

Calcium phosphate core
nanoparticles

Oligonucleotides Prone to degradation by nucleases Sokolova ( 2007a, b )

Hydroxyapatite needle-shaped
particles and plate-shaped
particles

cis -diamminedichloroplatinum(II)
(CDDP,cisplatin),
di(ethylenediamineplatinum)
medronate (DPM), bisphosphonate
alendronate

Lacks in vivo work to demonstrate
stability of drug under
physiological conditions

Palazzo ( 2007 )

Calcium phosphate core
nanoparticles

5,10,15,20-tetrakis(4-
phosphonooxyphenyl)porphine
(p-TPPP)

Lacks in vivo work to corroborate
stability of drug under
physiological conditions

Ganesan ( 2008 )

Combination structure
System

Active agent Remarks Reference

Calcium phosphate core
nanoparticles

Oligonucleotides Outer layer is prone to degradation

while internal layer of active
agent is protected

Sokolova ( 2007a, b )

Calcium phosphate core -
polymer shell

5,10,15,20-Tetrakis(3-hydroxyphenyl)-
porphyrin (mTHPP)

Outer layer is prone to degradation Klesing ( 2010 )

No improvement in efficiency over
free dye
Issues with toxicity of PEI