Calcium Phosphate and Calcium Phosphosilicate Mediated Drug Delivery and Imaging - Intracellular Delivery: Fundamentals and Applications - page 724

Table 1 Calcium phosphate based nanoparticulate systems
Architectures of select calcium phosphate based nanoparticulate systems
Encapsulation
System Active agent Remarks Reference

Calcium phosphosilicate Indocyanine green, ceramide C10, Cy3

amidite, cascade blue, fluorescein,
rhodamine WT, 10-(3-sulfopropyl)
acridinium betaine (SAB)

Successfully demonstrated
encapsulation of a range of
fluorophores with verified ability
to encapsulate drugs and nucleic
acids

Altınoğlu ( 2008 ),
Kester ( 2008 ),
Morgan ( 2008 ),
Muddana ( 2009 ),
Barth ( 2010 )

Polymer core,
CaP shell

b-Carotene Demonstrates encapsulation with

prospects in imaging and drug
and gene delivery

Perkin ( 2005 )

Hydroxyapatite hollow
nanoparticles

Vancomycin Hollow structure permits higher

payload concentrations

Ye ( 2010 )

Triblock co-Polymer-calcium
phosphate nanoparticles

Ibuprofen Ability to encapsulate hydrophobic

drugs

Cao ( 2010 )

Lipid coated calcium phosphate
nanoparticles

Plasmid DNA Higher DNA transfection efficiency

compared to standard methods

Zhou ( 2010 )

Calcium phosphate shell
liposome
core nanoparticles

carboxySNARF-1 Higher resistance to photobleaching

compared to free dye

Chen ( 2010 )

Calcium phosphate
apatite doped
particles

Europium Applications in optical imaging Al-Kattan ( 2010 )