Biomedical Engineering Reference
In-Depth Information
Calcium Phosphate and Calcium
Phosphosilicate Mediated Drug Delivery
and Imaging
O.A. Pinto, A. Tabaković, T.M. Goff, Y. Liu, and J.H. Adair
Abstract
Nanotechnology-based imaging, drug and gene delivery systems can be
used to improve current diagnostic and therapeutic approaches. Calcium phosphate
(CP) and calcium phosphosilicate (CPS) based nanoparticulate systems are becom-
ing increasingly popular as delivery vehicles for therapeutic and imaging agents due
to biocompatible and biodegradable properties of the material. In this chapter, we
emphasize properties of the various calcium phosphates that make these materials
promising nanocarriers and we provide an overview of the architectures of different
calcium phosphate systems including the nanocomposite calcium phosphosilicate
nanoparticles, hybrid CP-liposome and CP-polymeric systems. The versatility of
calcium phosphate based delivery systems for therapeutic and imaging applications
is emphasized.
Keywords
Bioimaging • Calcium phosphate • Calcium phosphosilicate • Drug
delivery • Gene delivery • Nanoparticles • Targeted delivery
List of Acronyms/Abbreviations
7-OH-DPAT 7-hydroxy-2-dipropyl-aminotetralin
AAV adeno-associated virus
ADP adenosine diphosphate
ATP adenosine triphosphate
ACP amorphous calcium phosphate
APTES aminopropyltriethoxysilane
carboxySNARF-1 carboxy-seminapthorhodafluor
O.A. Pinto, A. Tabaković, T.M. Goff, Y. Liu, and J.H. Adair (
*
)
Department of Materials Science and Engineering, Penn State University,
University Park, PA 16802, USA
e-mail: jha3@psu.edu
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