Biomedical Engineering Reference
In-Depth Information
CD71 Cluster of Differentiation 71 (an antibody for the transferrin receptor)
CEPA carboxyethylphosphoric acid
CER
6
hexanoyl-ceramide
CER
10
decanoyl ceramide
CHM cholesterol-bearing mannan
CHP cholesterol-bearing pullalan
CP calcium phosphate
CPS calcium phosphosilicate
CPSNPs calcium phosphosilicate nanocomposite particles
CPP casein phosphopeptides
Cy3 Cy3 Amidite
DMSO dimethyl sulfoxide
DNA deoxyribonucleic acid
DOPA 1,2-dioleoylsn-glycero-3-phosphate
DOTAP 1, 2-dioleoyl-3-trimethylammonium-propane chloride salt
DPBS Dulbecco's phosphate buffered saline
DSPE-PEG 1,2-distearoryl-sn-glycero-3-phosphoethanolamine-N-[methoxy
(polyethyleneglycol-2000) ammonium salt
EPC
L-a-phosphatidylcholine
EPR
enhanced permeation and retention
FCS
fluorescence correlation spectroscopy
HA
hydroxyapatite
ICG
indocyanine green
LD50
(
median) lethal dose, 50%
LCP
lipid coated calcium phosphate
LNCP
lipid-coated nano-calcium-phosphate
MPS
mononuclear phagocytic system
MTT
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
PBS
phosphate buffered saline
PEG
polyethylene glycol
RES
reticuloendothelial system
RNA
ribonucleic acid
RNAi
RNA interference
siRNA
small interfering RNA
ZP
zeta potential
1
Introduction
Conventional chemotherapeutic treatments have side effects caused by the systemic
delivery and interaction of the drug with healthy, non-cancerous cells (Alagna
2001
; Margolis
2005
). Reducing or eliminating side effects caused by therapeutics
and improving diagnostics by enhanced imaging agents is an area that has been
under investigation for a number of years (Langer
1990
; Tomlinson
1987
;
Leong
1988
). Approaches to improve diagnosis and treatment include employing
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