Magnetic Resonance Tracking of Stem Cells with Iron Oxide Particles - Intracellular Delivery: Fundamentals and Applications - page 459

Magnetic Resonance Tracking of Stem Cells
with Iron Oxide Particles
Eddy S.M. Lee, Brian K. Rutt, Nicholas M. Fisk,
Shih-Chang Wang, and Jerry Chan
Abstract Stem cells transplantation is a promising therapy for numerous diseases
where transplanted cells repair or replace damaged host tissue. While their efficacy
and optimal delivery is under intense investigation, there lies a pivotal question
seeking the whereabouts of the cells after transplantation. Imaging techniques have
emerged in recent years, both to enable monitoring of stem cell location in patients
and to improve the reliability of animal experimentation. Magnetic resonance
imaging (MRI) allows tracking of stem cells tagged with magnetic nanoparticle labels
E.S.M. Lee ( * )
Richard M. Lucas Center for Imaging, Radiology Department, Stanford University,
1201 Welch Road, Stanford, CA 94305-5488, USA
and
UQ Centre for Clinical Research, University of Queensland, Brisbane, QLD 4029, Australia
e-mail: [e-mail]
B.K. Rutt
Richard M. Lucas Center for Imaging, Radiology Department, Stanford University,
1201 Welch Road, Room PS064, Stanford, CA 94305-5488, USA
N.M. Fisk
UQ Centre for Clinical Research, University of Queensland, Brisbane, QLD 4029, Australia
S.-C. Wang
Discipline of Medical Imaging, University of Sydney, Sydney, NSW 2006, Australia
and
Department of Radiology, Westmead Hospital, Wentworthville, NSW 2145, Australia
J. Chan
UQ Centre for Clinical Research, University of Queensland, Brisbane, QLD 4029, Australia
and
Experimental Fetal Medicine Group, Department of Obstetrics and Gynecology,
Yong Loo Lin School of Medicine, National University of Singapore,
5 Lower Kent Ridge Road, Singapore 119074, Singapore
and
Department of Reproductive Medicine, KK Women's and Children's Hospital,
100 Bukit Timah Road, Singapore 229899, Singapore