Circadian Organization of the Immune Response: Rat Adjuvant Arthritis as a Model - New Insights to Neuroimmune Biology - page 121

Table 6.2 ( Continued)

24-Hour Rhythms Amplitude Acrophase Mean

Anterior hypothalamus
CRH

Suppression of rhythm Suppression of rhythm Decreased

TRH Suppression of rhythm Suppression of rhythm Decreased

GHRH Unchanged Changed Unchanged

Somatostatin Unchanged Changed Unchanged

NE Decreased Unchanged Decreased

DA turnover Decreased Unchanged Unchanged

5-HT turnover Decreased Unchanged Decreased

Medial hypothalamus
CRH

Unchanged Unchanged Unchanged

TRH Suppression of rhythm Suppression of rhythm Decreased

GHRH Unchanged Unchanged Unchanged

Somatostatin Unchanged Unchanged Unchanged

NE Decreased Unchanged Decreased

DA turnover Decreased Unchanged Decreased

5-HT turnover Decreased Unchanged Unchanged

Posterior hypothalamus
CRH

Unchanged Unchanged Unchanged

TRH Unchanged Unchanged Unchanged

GHRH Unchanged Unchanged Unchanged

Somatostatin Unchanged Unchanged Unchanged

NE Unchanged Changed Unchanged

DA turnover Decreased Unchanged Decreased

5-HT turnover Unchanged Changed Unchanged

Pineal gland
Melatonin

Unchanged Unchanged Unchanged

We also examined the changes in circadian rhythms of CNS and hypophysial
hormones and neurotransmitters during the acute phase of Freund's adjuvant arthri-
tis (i.e., 18 days after FCA administration) ( Table 6.3 ). Differing from the relative
compensation of circadian immune changes seen at this time of arthritis, changes in
24-hour rhythms of neuroendocrine parameters persisted during the clinical phase
of the disease [108] . Daily rhythms in plasma LH, testosterone, and TSH became