Biology Reference
In-Depth Information
Fig. 20.3 A 14-step mechanism of the alcohol-potentiated acetaminophen hepatotoxicity. This
figure was constructed around 1987 on the basis of the experimental observations reported in Ji
et al. (1988)
Uncertainty Principle to estimate the uncertainties (i.e., Kosko entropies) associated
with all of the mechanistic statements published so far about the acetaminophen
hepatotoxicity in humans based on animal experimental data and epidemiology.
Finally, in a qualitative sense, the
Toxicological Uncertainty Principle
may be
formulated by extending
Einstein's Uncertainty Thesis
(see Statement 5.38 in Sect.
