Applying the AIM Concept in Support of Developing Improved In Vitro–In Vivo Relationships for OIPs - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 375

Fig. 12.9 “Alberta” idealized adult anatomic throat (AIT) commercialized by Copley Scientifi c
Ltd, as inlet to an NGI ( Courtesy of Copley Scientifi c Ltd )

Fig. 12.10 Opened “Alberta” idealized adult anatomic throat (AIT) showing fl ow pathway
( Courtesy of Copley Scientifi c Ltd )

12.3 Validation of an AIM-pHRT System Based on the ACI

In Chap. 10 , the description of the in vitro evaluation of a prototype AIM-pHRT
system based on the ACI and confi gured to have stage d 50 values in accordance with
Fig. 12.7 was validated as one arm of a systematic investigation of precision and
accuracy of this system, an AIM-QC impactor, with a full-resolution ACI as the