Validating AIM-Based Instrumentation and Associated Measurement Techniques - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 324

Fig. 10.50 Comparison between NGI and FSI for measures of TEM and FPM <5.0μm reported by
Després-Gnis and Williams (error bars correspond to ±1 SD) ( From [ 48 ]— courtesy of G. Williams )

Fig. 10.51 FSI performance with and without stage coating reported by Després-Gnis and
Williams (error bars correspond to ±1 SD) ( From [ 48 ]— courtesy of G. Williams )

proved unnecessary with a single actuation of the DPI, based on comparative tests
showing no statistical difference between TEM and FPF <5.0μm measured with and
without the application of a standard stage coating prepared from a solution of 1%
v/v glycerol in ethanol (Fig. 10.51 ).
Nevertheless, even though these differences were not statistically significant,
mean TEM with coating (207.2 g/actuation) was numerically greater than the cor-

responding value uncoated (190.2

μ

g/actuation) suggesting that further examina-
tion of the stage coating methodology might still be beneficial, possibly resorting

μ