Validating AIM-Based Instrumentation and Associated Measurement Techniques - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 291

Fig. 10.11 Comparison of performance metrics in precision study: ( a ) ISM by impactor type; ( b )
ISM by inhaler number; ( c ) ratio LPM/SPM by impactor type; ( d ) LPM/SPM by inhaler number;
( e ) FPM by impactor type; and ( f ) FPM by inhaler number ( From [ 26 ]— used with permission )

Table 10.6 Summary statistics and 95% Confidence Intervals (CIs) on ratio of standard deviations
of AIM-pHRT system to nonviable ACI for metrics relating to inhaler APSD ( From [ 26 ]— used
with permission )

95% CI on ratio of
SDs of abbreviated
to full configuration

Impactor
configuration

SD [repeatabi-
lity] (

Coefficient of
variation (%) Metric Mean ( μ g) μ g)

CPM ACI 44.08 2.87 6.52 [0.57; 1.89]

AIM-pHRT 45.17 3.00 6.64

FPM ACI 35.43 1.40 3.88 [0.69; 2.25]

AIM-pHRT 35.00 1.74 4.97

EPM ACI 2.21 0.74 33.72 [0.73; 2.40]

AIM-pHRT 7.93 0.99 12.44