Good Cascade Impactor Practices - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 101

Table 4.3 Representation of data from full-resolution CI measurements
Approach Advantage Application

API mass on each component
including non-sizing parts,
such as the induction port

Simplicity OIP quality control

API mass on each size-
fractionation stage of the CI

Basic aerodynamic
size-related
information

OIP development and in
bioequivalence

API mass mathematically
linked to aerodynamic
diameter range of sizing
stages

Aerodynamic size-
related information
comparable from one
CI system to another

OIP development and in bioequiva-
lence; this approach is essential
for input to models predicting
respiratory tract deposition

Fig. 4.7 Representation of CI raw data by mass deposition in both sizing and non-sizing compo-
nents ( From [ 78 ]— used by permission )

Fig. 4.8 API mass on CI size-separating stages as an ordinal function of stage d 50 size: example
from ACI operated at 28.3 L/min ( From [ 78 ]— used by permission )