Chemistry Reference
In-Depth Information
Fig. 3 Structures of dual-function agents in which the HPPH is conjugated to a cyanine dye
containing bis-benzoindole and bis-indole moieties with amide linkages
Scheme 1 Purpurinimide-CD conjugates. Among these analogs, the conjugate X (R
ΒΌ
CH
2
-CH
2
) showed improved PDT efficacy than the HPPH-CD conjugate in BALB/c mice bearing
Colon26 tumors
brief, the reaction of
meso-
substituted purinimide with
N
-bromosuccinimide
regioselectively introduced a bromo-functionality at position-20, which on further
reacting with a variety of boronic acids under Suzuki reaction conditions yielded
the corresponding
meso
-substituted analogs (Scheme
2
).
