Biomedical Engineering Reference
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12. Tirona, RG, Tan E, Meier G, Pang KS. 1999. Uptake and glutathione conjugation kinetics
of ethacrynic acid in rat liver: in vitro and perfusion studies. J Pharmacol Exp Ther
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13. Pang KS, Terrell JA. 1981. Retrograde perfusion to probe the heterogeneous distribution
of hepatic drug metabolizing enzymes in rats. J Pharmacol Exp Ther 216:339-346.
14. Abu-Zahra TN, Pang KS. 2000. Effect of zonal transport and metabolism on hepatic
removal: enalapril hydrolysis in zonal, isolated rat hepatocytes in vitro and correlation
with perfusion data. Drug Metab Dispos 28:807-813.
15. Hjelle JJ, Hazelton GA, Klaassen CD. 1985. Acetaminophen decreases adenosine 3 -
phosphate 5 -phosphosulfate and uridine diphosphoglucuronic acid in rat liver. Drug
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16. Dills RL, Howell SR, Klaassen CD. 1987. Hepatic UDP-glucose and UDP-glucuornic
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17. Wagner JG, DiSanto AR, Gillespie WR, Albert KS. 1981. Reversible metabolism and
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19. Cheng HY, Jusko WJ. 1990. Mean interconversion times and distribution rate parameters
for drugs undergoing reversible metabolism. Pharm Res 7:1003-1110.
20. Ratna S, Chiba M, Bandyopadhyay L, Pang KS. 1993. Futile cycling between 4-
methylumbelliferone and its conjugates in perfused rat liver. Hepatology 17:838-853.
21. Tan E, Pang KS. 2001. Sulfation is rate limiting in the futile cycling between estrone and
estrone sulfate in enriched periportal and perivenous rat hepatocytes. Drug Metab Dispos
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22. Tan E, Lu T, Pang KS. 2001. Futile cycling of estrone sulfate and estrone in the recircu-
lating, perfused rat liver. J Pharmacol Exp Ther 297:423-436.
23. Pang KS, Sherman IA, Schwab AJ, Geng W, Barker F III, Dlugosz JA, Cuerrier G,
Goresky CA. 1994. Role of the hepatic artery in the metabolism of phenacetin and ac-
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rat liver. Hepatology 20:672-683.
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and portal flow interactions in perfused rat liver: an intravital microscopic study. Am J
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WC, Quarfordt SH. 2003. Effect of hepatic artery flow on bile secretory function after
cold ischemia. Am J Transplant 3:148-155.
27. Pang KS, Rowland M. 1977. Hepatic clearance of drugs: II. Experimental evidence for
acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in
the perfused rat liver in situ preparation. J Pharmacokinet Biopharm 5:655-680.
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